2. Signaling Pathways
  3. Vitamin D Related/Nuclear Receptor
  4. Progesterone Receptor

Progesterone Receptor

NR3C3

Progesterone Receptor

Related Products

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Progesterone receptor (PR) is a member of the steroid/thyroid hormone-retinoid receptor superfamily of ligand-activated nuclear transcription factors. Progesterone receptor plays a vital role in female reproductive tissue development, differentiation, and maintenance.

Progesterone receptor is able to bind to a large number and variety of ligands that elicit a broad range of transcriptional responses ranging from full agonism to full antagonism and numerous mixed profiles inbetween. Progesterone receptor, such as progesterone, induces conformation changes in PR ligand binding domain (LBD), thus mediates subsequent gene regulation cascades.

In humans, the biological response to progesterone is mediated by two distinct forms of the progesterone receptor (human PR-A and PR-B).

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0521
    Altrenogest
    		Agonist 99.86%
    Altrenogest (Allyltrenbolone) is a progestogen structurally related to veterinary steroid trenbolone.
    Altrenogest
  • HY-119384
    Promegestone
    		Agonist ≥98.0%
    Promegestone (R-5020), a progestin, is a potent progesterone receptor (PR) agonist. Promegestone has the potential for endocrine regulation and cancer research.
    Promegestone
  • HY-12516
    Desogestrel
    		Agonist 99.65%
    Desogestrel (Org-2969) is a third-generation progesterone analogue contained in many oral contraceptive preparations. Desogestrel is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Desogestrel
  • HY-15606
    Tanaproget
    		Agonist 99.87%
    Tanaproget is an orally effective, selective nonsteroidal progesterone receptor (PR) agonist targeting human PR with an IC50 of 1.7 nM. Tanaproget promotes the interaction between PR receptors and coactivators (such as SRC-1), thereby inhibiting the secretion of matrix metalloproteinases (MMP-3/MMP-7) and reducing endometrial tissue invasion and angiogenesis. Tanaproget can be used for contraception and endometriosis inhibition research.
    Tanaproget
  • HY-A0285
    Norethisterone enanthate
    		99.53%
    Norethisterone enanthate is a long-acting parenteral progestogen. Norethisterone enanthate is orally active. Norethisterone enanthate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norethisterone enanthate
  • HY-B0469R
    Medroxyprogesterone acetate (Standard)
    		Agonist 99.24%
    Medroxyprogesterone acetate (Standard) is the analytical standard of Medroxyprogesterone acetate. This product is intended for research and analytical applications. Medroxyprogesterone acetate is a widely used synthetic steroid by its interaction with progesterone, androgen and glucocorticoid receptors.
    Medroxyprogesterone acetate (Standard)
  • HY-B0110
    Gestodene
    		Agonist 99.90%
    Gestodene(SHB 331;WL 70) is a progestin-based contraceptive. Gestodene is a click chemistry reagent. It contains an alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing an azide group.
    Gestodene
  • HY-13071
    Nestoron
    		Agonist 99.83%
    Nestoron (ST-1435) is a 19-norprogesterone derivative with high affinity and selectivity for progesterone receptors. Nestoron is a highly selective and potent progestogen that can be used as a hormonal contraceptive.
    Nestoron
  • HY-B0648R
    Medroxyprogesterone (Standard)
    		Agonist 99.29%
    Medroxyprogesterone (Standard) is the analytical standard of Medroxyprogesterone. This product is intended for research and analytical applications.
    Medroxyprogesterone (Standard)
  • HY-119433
    Asoprisnil
    		Modulator 98.30%
    Asoprisnil (J867), a selective progesterone receptor modulator, exhibits mixed progesterone agonist and antagonist effects on various progesterone targeted tissues in animal and human.
    Asoprisnil
  • HY-17375
    Allylestrenol
    		98.91%
    Allylestrenol is an orally active synthetic anti-androgen sexualsteroid. Allylestrenol can prevent miscarriage in vivo. Allylestrenol significantly affects testosterone progesterone level in rat model. Allylestrenol can reduce ventral prostate weight in rat model.
    Allylestrenol
  • HY-B1710
    Norethindrone acetate
    		99.11%
    Norethindrone acetate is a female hormone used for the research of endometriosis. Norethindrone acetate is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Norethindrone acetate
  • HY-105634A
    Nomegestrol acetate
    		Agonist 99.73%
    Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate inhibits ovulation. Nomegestrol acetate is also effective in inhibiting the proliferation of human endometrial cancer RL95-2 cells in vitro and in vivo. Nomegestrol acetate can be used in cancer (especially endometrial cancer) and contraceptive studies.
    Nomegestrol acetate
  • HY-B0891R
    17α-Hydroxyprogesterone (Standard)
    		Agonist
    17α-Hydroxyprogesterone (Standard) is the analytical standard of 17α-Hydroxyprogesterone. This product is intended for research and analytical applications.
    17α-Hydroxyprogesterone (Standard)
  • HY-B1095
    Chlormadinone acetate
    		Agonist ≥98.0%
    Chlormadinone acetate is a steroidal progestin, with antiandrogen and antiestrogenic effects.
    Chlormadinone acetate
  • HY-N0437S
    Progesterone-d9
    		Agonist 99.97%
    Progesterone-d9 is the deuterium labeled Progesterone. Progesterone is a steroid hormone that regulates the menstrual cycle and is crucial for pregnancy.
    Progesterone-d<sub>9</sub>
  • HY-111614S2
    Melengestrol acetate-d3
    		Activator 99.27%
    Melengestrol acetate-d3 is the deuterium labeled Melengestrol acetate. Melengestrol acetate is a progesterone derivative, acts as an orally active corticosteroid hormone to promote endometrial proliferation, pregnancy maintenance, and delay of menstrual activity. Melengestrol Acetate is used as a contraceptive agent for growth promoting effects and suppression of estrus in animals. Melengestrol acetate inhibits both the androgen-dependent and -independent prostatic tumors in vivo and can be used for cancer research.
    Melengestrol acetate-d<sub>3</sub>
  • HY-B0652
    Etonogestrel
    		Agonist 99.91%
    Etonogestrel (3-Oxodesogestrel), a biologically active metabolite of progestin Desogestrel, binds with high affinity to progesterone receptors and estrogen receptors in the target organs. Etonogestrel induce FKBP51 mRNA and protein expression in cultured human endometrial stromal cells (HESCs).
    Etonogestrel
  • HY-B2245
    Estradiol dipropionate
    		Agonist 99.85%
    Estradiol dipropionate is a combined estrogen-progesterone, acts as an estrogen and progesterone agonist.
    Estradiol dipropionate
  • HY-131547
    Org OD 02-0
    		Agonist 99.7%
    Org OD 02-0 (10-Ethenyl-19-norprogesterone) is a membrane progesterone receptor α (mPRα)-specific agonist (IC50: 33.9 nM). Org OD 02-0 activates MAPK activity. Org OD 02-0 inhibits prolactin (PRL) secretion in the pituitary.
    Org OD 02-0
Cat. No. Product Name / Synonyms Application Reactivity